Xing Laboratory of RNA Genomics and Bioinformatics

News and Events

  • May 2017: Our R01 grant to study the variation and regulation of alternative splicing in mammalian transcriptomes is renewed by the NIH for four more years.

  • February 2017: Dr. Xing joins the Scientific Advisory Committee of the Center for Dynamic RNA Epitranscriptomes at the University of Chicago. This is a Center for Excellence in Genomic Sciences (CEGS) funded by the National Human Genome Research Institute, with the main focus being to develop single base, quantitative, and sensitive sequencing methods for RNA modifications.

  • January 2017: Our m6A-LAIC-seq method for m6A level and isoform characterization sequencing is highlighted by Nature Methods "Method of the Year 2016" review for "Epitranscriptome Analysis".

  • January 2017: Bioinformatics Ph.D. student Zijun Zhang was awarded a Keystone Symposia Future of Science Fund to present his work at the meeting "Omics strategies to study the proteome".

  • September 2016: We received a research grant from the Parker Institute for Cancer Immunotherapy.

  • September 2016: We received an R01 grant from the NIH Big Data to Knowledge (BD2K) initiative to develop statistical methods and informatics pipelines for integrating transcriptomic and proteomic big data.

  • July 2016: We received a National Institute of Mental Health (NIMH) R01 grant (with Drs. Douglas Black and Kathrin Plath) to study alternative splicing regulation in the mammalian brain.

  • July 2016: Jinkai's work on m6A-LAIC-seq (m6A level and isoform characterization sequencing) is published by Nature Methods. See UCLA news release, GenomeWeb news story, and News & Views by Nature Methods.

  • June 2016: Shihao's SURVIV paper is published by Nature Communications. SURVIV is a statistical method for survival analysis of mRNA isoform variation in cancer transcriptomes. See UCLA news release and GenomeWeb news story.

  • January 2016: Lan's work on primate-specific, protein-coding Alu exons is published by Genome Biology (also see "Proteome diversification by genomic parasites", research highlight by Eli Eisenberg).

  • Nov 2014: Shihao and Juw Won's rMATS paper has been accepted for publication by PNAS. rMATS is a computational tool to detect differential alternative splicing events from replicate RNA-Seq data. [rMATS software]

  • Oct 2014: Shihao received a 2-year Human Biology Fellowship from the Huntington’s Disease Society of America (HDSA) on “Transcriptome Isoform Networks in Huntington’s Disease”. Congratulations! [HDSA press release]

  • Oct 2014: We received a Developmental Research Program Award from the UCLA SPORE in Prostate Cancer.

  • Sep 2014: Jinkai Wang's work in collaboration with Drs. Cosmas Giallourakis (MGH) and Howard Chang (Stanford) on m6A RNA methylation of mammalian embryonic stem cells is in press at Cell Stem Cell.

  • Sep 2014: We received a 2-year R01 grant from the NIH Roadmap Initiative to study epigenomic control of RNA processing.

  • Aug 2014: Our work in collaboration with Dr. Yang Shi (Harvard) on a chromatin regulator of intron retention has been accepted for publication by Molecular Cell.

  • Oct 2013: Our work with Beverly Davidson (University of Iowa) on mapping microRNA binding sites in the human brain will appear in the journal Neuron.

  • Sep 2013: We received a 5-year NIH R01 grant (R01NS076631) from the National Institute of Neurological Disorders and Stroke (NINDS) to study the transcriptome landscape of Huntington's disease.

  • Jun 2013: Dr. Yi Xing is appointed as a regular member of the NIH GCAT (Genomics, Computational Biology and Technology) study section (2013-2019).

  • Jun 2013: We received a one-year research award from the UCLA Broad Stem Cell Research Center (BSCRC).

  • Feb 2013: Dr. Yi Xing received a 2013 Alfred P. Sloan Research Fellowship. [Sloan Foundation news] [UCLA news]

  • Jan 2013: Xing lab moved to the Department of Microbiology, Immunology, and Molecular Genetics at UCLA.

  • Dec 2012: Shihao Shen received his Ph.D. degree in Biostatistics.

  • Dec 2012: Ji Wan received his Ph.D. degree in Genetics.

  • Jul 2011: Lan Lin received a KL2 career development award in clinical and translational science to develop RNA based translational genomics technologies.

  • Mar 2011: Our research about primate-specific Alu exons was featured in the NIH Biomedical Beat news digest.

  • Feb 2011: We received a 4-year research grant from the Burroughs Wellcome Fund to study transcriptome genetics of human pregnancy.

  • Jan 2011: Group research accepted for publication by PNAS and Human Molecular Genetics.

  • Jan 2011: Shihao Shen received a University of Iowa Graduate College Strategic Initiative Fellowship.

  • Jul 2010: We received NIH R21 grants from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung and Blood Institute (NHLBI).

  • Apr 2010: We received a 5-year NIH R01 grant (R01GM088342) from the National Institute of General Medical Sciences.

  • Feb 2010: We received a NIDDK pilot grant from the UI Center for Gene Therapy.

  • Jan 2010: We received a Basil O'Connor Starter Scholar Research Award from the March of Dimes Foundation.

  • Jan 2010: Lan Lin received a postdoctoral travel fellowship to the ASBMB (American Society for Biochemistry and Molecular Biology) annual meeting.

  • Oct 2009: We received a junior faculty award from the Edward Mallinckrodt Jr Foundation, and research grants from the Burroughs Wellcome Fund and the FSH Society.

  • Mar 2009: We received a Department of Internal Medicine 2009 pilot grant on clinical and translational research.
  • Mar 2009: Our paper "Large-scale analysis of exonized mammalian-wide interspersed repeats (MIRs) in primate genomes" is accepted by Human Molecular Genetics.
  • Dec 2008: Congratulations to Lan Lin for winning an ASBMB (American Society for Biochemistry and Molecular Biology) Postdoctoral Travel Fellowship!
  • Nov 2008: We received a research grant from the National Human Genome Research Institute on "Statistical Analysis of Exon Arrays" (R01-HG004634, to Wing Hung Wong and Yi Xing) .
  • Oct 2008: Seiko Sato joins the lab as a technician. Seiko received her BS in Biology from Cornell University.
  • Sept 2008: Congratulations to Anne Tye, who won an ICRU (Iowa Center for Research by Undergraduates) Scholar Assistant Award!
  • Jan 2008: Our Genes and Development 2007 article (Genes Dev. 21, 2963-2975) is highlighted by Cell Leading Edge.
  • Jan 2008: book chapter on alternative splicing in the book of "Alternative Splicing in the Postgenomic Era", Benjamin Blencowe and Brenton Graveley eds. [order book ]
  • Dec 2007: we received a research grant from the Hereditary Disease Foundation.
  • Oct 2007: a new paper "Global analysis of alternative splicing differences between humans and chimpanzess" is accepted by Genes and Development. [news report]
  • NSF-IMA Workshop: RNA in Biology, Bioengineering and Nanotechnology, 10/29/2007-11/02/2007, Minneapolis, MN, USA